Candice Klingerman, Associate Professor

Candice Klingerman, Associate Professor


Candice Klingerman

Education

Ph.D. Lehigh University, Integrative Biology; M.S. University of Delaware, Animal Science; B.S. Delaware Valley College, Animal Science

Teaching

Introduction to Nutrition, Concepts in Biology 1 laboratories, Anatomy and Physiology laboratories, Current Topics in Biology

Research Interests

Areas of Research Specialization: Behavioral Neuroendocrinology

My research laboratory is dedicated to understanding the neuroendocrine mechanisms underlying diseases of energy dysregulation (e.g. obesity, anorexia). These mechanisms are studied from an evolutionary perspective – traits evolve if they increase reproductive success. Therefore, we examine both ingestive as well as reproductive behaviors simultaneously, using zebrafish as our animal model.

Research Group

My laboratory's primary research area is the link between energy balance and reproduction in male and female animals. Trying to understand and treat diseases of energy dysregulation, i.e. obesity and anorexia, is difficult and has been misunderstood for decades. Instead, we link energy balance to another evolutionary process, reproductive success. Reproductive success is based upon the concept that any adaptive trait that mammals have developed, such as the ability to carry very high levels of subcutaneous and intra-abdominal fat, did so because they increased the probability of a successful mating.

Currently, we are using zebrafish as our animal model to study various aspects of behavior. A small colony of zebrafish, housed in Hartline Science Center, provide students in my research laboratory the opportunity to research a number of topics. Most recently, a Master’s degree candidate, John Poling, researched how environmental neurotoxins contribute to behavioral deficits in learning and memory. Similar to my research interests, future experiments will examine if limited food availability has any effect on sexual behavior or reproductive success of these fish.

Grants

  • 2016-2017. Food-restriction affects reproductive and ingestive behaviors in zebrafish (Danio rerio); Effects of environmental neurotoxins on learning and memory of zebrafish. Research and Scholarship Grant provided by Bloomsburg University
  • 2014-2015. Effects of neuropeptide Y, ghrelin, and leptin on reproductive and ingestive behaviors of Syrian hamsters. Research and Scholarship Grant provided by Bloomsburg University
  • 2015. Bloomsburg University Teacher-scholar grant

Representative Publications

  • Schneider, J., Benton, N., Russo, K., Klingerman, C., Williams, W., Simberlund, J., Abdulhay, A., Brozek, J., and Kriegsfeld, L. (2017) RFamide-related Peptide-3 and the Trade-off Between Reproductive and Ingestive Behavior. Integr Comp Biol. 57:1225-1239.
  • Klingerman, C.M., M. Stipanovic, A. Hajnal, and C. Lynch. (2015) “Acute metabolic effects of olanzapine depend on dose and injection site.” Dose-response. 13:1-8
  • Abdulhay, A.A., N. Benton, C.M. Klingerman, K. Krishnamoorthy, J. Brozek, and J. E. Schneider. (2014) “Estrous cycle fluctuations in sex and ingestive behavior are accentuated by exercise or cold ambient temperatures.” Horm Behav 66:135-147.
  • Klingerman, C.M., M.E. Stipanovic, M. Bader, and C.J. Lynch. (2014) “Second generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.” Schizophrenia Bulletin. 40:327-340.

Representative Theses, Directed Studies, and Departmental Papers

  • Poling, J. 2018. “The effects of neurotoxins on the memory, cognitive ability, and social behavior of zebrafish (Danio rerio). Master’s Thesis.
  • Burroughs, S.E. 2017. “Ghrelin and prokineticin-2 are affecting the sexual and ingestive behaviors of the female Syrian hamster.” Master’s Thesis.
  • Dalsania, A.A. and Trautwein, T.L. 2017. “The various effects of Prokineticin 2 on the sexual behavior and food intake of Syrian hamsters” Undergraduate Directed Study Paper.
  • Boksmati, S.M. 2015. “Effects of neuropeptide Y on sexual and ingestive behavior of female Syrian hamsters.” Graduate Directed Study Paper.